Coexistence of Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia
نویسنده
چکیده
Analysis of the blood smear, bone marrow aspiration, and bone marrow biopsy revealed the predomination of small lymphocytes, but 22% of the cells were blasts negative with cytochemical staining (Figure 1). Flow cytometric analysis showed two distinct populations: 65% of cells were small to moderate in size and CD19+, CD45+, CD5+, and CD20+/-, while 30% of cells were large, CD34+, CD13+, HLA DR+, CD65+, CD45+, and MPO weakly positive and CD33, CD14, CD15, and CD16 negative. Immunophenotyping confirmed the coexistence of chronic lymphocytic leukemia and poorly differentiated acute myeloid leukemia. Conventional cytogenetic testing did not show any chromosomal abnormalities.
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